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Adv Exp Med Biol. 2012;740:159-82. doi: 10.1007/978-94-007-2888-2_7.

Ryanodine receptor calcium release channels: an evolutionary perspective.

Author information

1
Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. j.mackrill@ucc.ie

Abstract

Ryanodine receptors (RyRs), along with the related inositol 1,4,5-trisphosphate receptors (IP(3)Rs), mediate the release of Ca(2+) from intracellular organelles of eukaryotes. As discussed in other chapters, such increases in intracellular Ca(2+) levels act a fundamental second messenger, regulating a diverse array of cellular processes. For over two decades, it has been reported that vertebrates express multiple RYR genes, whereas non-vertebrate multicellular organisms possess a single homologue within their genomes. Recently, the existence of RyR-like channels in unicellular organisms has also been reported. This chapter exploits recent expansions in available genome data to generate an overview of the expression of RyR-like genes in organisms representing a broad range of viral, archaeal, bacterial and eukaryotic taxa. Analyses of the multidomain structures and phylogenetic relationships of these proteins has lead to a model in which, early during eukaryotic evolution, IP(3)R-like ancestral Ca(2+) release channels were converted to RyR proteins via the addition of promiscuous protein domains, possibly via horizontal gene transfer mechanisms.

PMID:
22453942
DOI:
10.1007/978-94-007-2888-2_7
[Indexed for MEDLINE]

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