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Dig Dis Sci. 2012 Aug;57(8):2038-44. doi: 10.1007/s10620-012-2134-3. Epub 2012 Mar 27.

Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid.

Author information

1
Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Rua José Kanan Aranha no 102, Porto Alegre, Rio Grande do Sul, CEP.: 91760-470, Brazil.

Abstract

AIM OF THE STUDY:

To evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats.

MATERIALS AND METHODS:

The extract of B. serrata (34.2 mg/kg/day) was administered orally by gavage for 2 days before and after induction of colitis with AA diluted to 4 % and in a volume of 4 ml.

RESULTS:

The anal sphincter pressure in the groups treated with B. serrata showed a significant increase compared to the colitis group (P < 0.001). Histological analysis of treated animals showed less edema with preservation of mucosal crypts. Lipid peroxidation showed a significant decrease in the treated groups compared to the colitis group (P < 0.001). The superoxide dismutase (SOD) enzyme activity showed a significant reduction in the treated groups compared to the colitis group (P < 0.001), the glutathione peroxidase (GPx) significantly increased in the treated groups compared to colitis group (P < 0.05), and the same was the result for enzyme activity glutathione (GSH; P < 0.05).

CONCLUSIONS:

The extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis.

PMID:
22451119
DOI:
10.1007/s10620-012-2134-3
[Indexed for MEDLINE]

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