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Bioorg Med Chem Lett. 2012 Apr 15;22(8):2760-3. doi: 10.1016/j.bmcl.2012.02.088. Epub 2012 Mar 7.

A new pancreatic lipase inhibitor from Broussonetia kanzinoki.

Author information

1
College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju, Republic of Korea.

Abstract

A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.

PMID:
22450131
DOI:
10.1016/j.bmcl.2012.02.088
[Indexed for MEDLINE]

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