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Am J Respir Crit Care Med. 2012 Jun 1;185(11):1154-65. doi: 10.1164/rccm.201111-2082CI. Epub 2012 Mar 23.

Pulmonary complications of sickle cell disease.

Author information

1
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA.

Abstract

Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity and mortality. The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.

PMID:
22447965
PMCID:
PMC3373067
DOI:
10.1164/rccm.201111-2082CI
[Indexed for MEDLINE]
Free PMC Article

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