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Nat Neurosci. 2012 Mar 25;15(5):700-2. doi: 10.1038/nn.3079.

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.

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1
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

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PMID:
22446882
PMCID:
PMC3380241
DOI:
10.1038/nn.3079
[Indexed for MEDLINE]
Free PMC Article

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