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Vaccine. 2012 May 14;30(23):3459-62. doi: 10.1016/j.vaccine.2012.03.019. Epub 2012 Mar 22.

Health and economic impact of the seasonal influenza vaccination programme in England.

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1
Health Protection Agency, United Kingdom.

Abstract

BACKGROUND:

The seasonal influenza vaccination programme in England targets individuals over 65 years old and in clinical risk groups.

METHODS:

A model of influenza transmission and disease was fitted to weekly primary care consultations due to influenza in a typical pre-pandemic season (2006/2007). Different scenarios were constructed about influenza severity and how well vaccines match circulating strains to assess the impact and cost-effectiveness of the current vaccination programme.

RESULTS:

A well-matched vaccine may reduce the incidence of laboratory-confirmed influenza illness from 8.2% (95% range 4.3-13%) to 5.9% (95% range 2.9-9.7%), with 56-73% of this due to indirect protection. The programme is likely to be cost-effective unless both low severity and poor matching is assumed.

CONCLUSION:

The current seasonal influenza vaccination programme appears to substantially reduce disease burden and provides good value for money.

PMID:
22446636
DOI:
10.1016/j.vaccine.2012.03.019
[Indexed for MEDLINE]
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