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Vaccine. 2012 May 2;30(21):3155-8. doi: 10.1016/j.vaccine.2012.02.068. Epub 2012 Mar 21.

Effect of needle length for response to hepatitis B vaccine in macrosomic neonates: a prospective randomized study.

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1
Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. ramazanoz@yahoo.com.tr

Abstract

OBJECTIVES:

The objective of this study was to determine whether use of a longer (1 in.) rather than a standard (5/8 in.) needle used for macrosomic neonates (birthweight over 4000 g) may affect antibody titers after immunization against hepatitis B virus (HBV).

METHODS:

Fifty nine healthy infants were vaccinated at birth, 1, and 6 months of age with hepatitis B vaccine, with follow up to 7 months of age. Infants were randomized into two groups according to needle length of first vaccine at birth. First group vaccinated with standart needle length and other group received vaccine by longer needle length.

RESULTS:

Macrosomic infants who were immunized with a longer needle achieved significantly higher antibody titers to hepatitis B surface antigen than standart needle length (median, 3890.2 vs 1311.7 mIU/mL, respectively; p=0.001).

CONCLUSIONS:

Macrosomic neonates benefit from longer needle length with higher levels of antibody titers after HBV vaccination.

PMID:
22446632
DOI:
10.1016/j.vaccine.2012.02.068
[Indexed for MEDLINE]
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