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Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. doi: 10.1016/j.bmcl.2012.02.105. Epub 2012 Mar 8.

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.

Author information

1
Gilead Sciences, 333 Lakeside Drive, Foster Cit, CA 94044, USA. acho@gilead.com

Abstract

A series of 1'-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.

PMID:
22446091
DOI:
10.1016/j.bmcl.2012.02.105
[Indexed for MEDLINE]

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