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Chem Biol. 2012 Mar 23;19(3):313-4. doi: 10.1016/j.chembiol.2012.03.002.

For MutY, it's all about the OG.

Author information

1
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. rws9@pitt.edu

Abstract

MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al. utilized mutant forms of MutY to reveal the critical residues in MutY that are required for this selectivity and specificity.

PMID:
22444586
PMCID:
PMC3891578
DOI:
10.1016/j.chembiol.2012.03.002
[Indexed for MEDLINE]
Free PMC Article

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