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Semin Immunol. 2012 Jun;24(3):175-89. doi: 10.1016/j.smim.2012.02.008. Epub 2012 Mar 22.

Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.

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Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, Epalinges, Switzerland.


Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery. More recently, IL-7 reporter mice and other approaches have led to the further characterization of the various stromal cell sources of IL-7 in secondary lymphoid organs (SLO) and other tissues. We will review these advances along with a discussion of the regulation of IL-7 and its receptor, and compare the biological effects IL-7 has on adaptive as well as innate immune cells in SLO. Finally, we will review the role of IL-7 in development of SLO and tertiary lymphoid tissues that frequently are associated with sites of chronic inflammation.

[Indexed for MEDLINE]

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