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Med Clin North Am. 2012 Mar;96(2):269-81. doi: 10.1016/j.mcna.2012.01.012. Epub 2012 Feb 14.

The effect of thyroid disorders on lipid levels and metabolism.

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1
Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou Street, 11528 Athens, Greece. ledunt@otenet.gr

Abstract

Thyroid hormones regulate cholesterol and lipoprotein metabolism, whereas thyroid disorders, including overt and subclinical hypothyroidism, considerably alter lipid profile and promote cardiovascular disease. Good evidence shows that high thyroid-stimulating hormone (TSH) is associated with a nonfavorable lipid profile, although TSH has no cutoff threshold for its association with lipids. Thyromimetics represent a new class of hypolipidemic drugs: their imminent application in patients with severe dyslipidemias, combined or not with statins, will improve the lipid profile, potentially accelerate energy expenditure and, as a consequence, vitally lessen the risk of cardiovascular disease.

PMID:
22443975
DOI:
10.1016/j.mcna.2012.01.012
[Indexed for MEDLINE]
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