Format

Send to

Choose Destination
Expert Opin Ther Targets. 2012 Apr;16 Suppl 2:S119-29. doi: 10.1517/14728222.2012.656092. Epub 2012 Mar 23.

Premetastatic niche: ready for new therapeutic interventions?

Author information

1
Campus Bio-Medico University, Department of Medical Oncology, Rome, Italy.

Abstract

INTRODUCTION:

Bone marrow-derived cells (BMDC) localize in premetastatic niche through chemokines and integrins signals and establish clusters that precede the arrival of even single metastatic tumor cell at distant site. CSCs demonstrate an increased metastatic propensity and would seem likely candidates for the acquisition of migratory capabilities and propagation of heterogeneous tumor cell populations to different target organs. Sonic Hedgehog (SHH), FOXM1 and Notch pathways and signaling molecules such as integrin and chemokine could dictate their fate.

AREAS COVERED:

In this review, the molecular mechanisms of premetastatic niche onset are summarized.

EXPERT OPINION:

Premetastatic niche is defined as a fertile microenvironment that forms in metastatic target organ and facilitates the invasion, survival and/or proliferation of metastatic tumor cells, providing a novel mechanism for the promotion of metastasis. Drugs targeting premetastatic niche could represent a new promising therapeutic approach in the treatment of bone metastases.

PMID:
22443277
DOI:
10.1517/14728222.2012.656092
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center