Format

Send to

Choose Destination
J Surg Oncol. 2012 Apr 1;105(5):444-51. doi: 10.1002/jso.21856.

Translational advances regarding hereditary breast cancer syndromes.

Author information

1
National Capital Area Breast Care Center, National Naval Medical Center, Bethesda, Maryland, USA.

Abstract

Approximately 5-10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non-BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing and interpretations.

PMID:
22441895
DOI:
10.1002/jso.21856
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center