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Neurosurg Clin N Am. 2012 Apr;23(2):227-35, vii-viii. doi: 10.1016/

Characteristics and treatment of seizures in patients with high-grade glioma: a review.

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  • 1UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0138, San Francisco, CA 94143, USA.


High-grade gliomas (HGGs), including anaplastic astrocytoma and glioblastoma multiforme, are the most common primary brain tumors, and are often associated with seizures. Seizure control is a critical but often underappreciated goal in the treatment of patients harboring these malignant lesions. Patients with HGG who also have medically intractable seizures should be considered for a palliative resection guided by electrocorticography and functional mapping. Antiepileptic drugs remain the mainstay of seizure treatment in HGG, and antiepileptic medication should be started after a tumor-related seizure, but should not be used prophylactically in the absence of seizure activity.

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