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Am J Clin Nutr. 2012 May;95(5):1209-14. doi: 10.3945/ajcn.111.030817. Epub 2012 Mar 21.

PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women.

Author information

1
Department of Nutrition and Life Science, Faculty of Life Science and Biotechnology, Fukuyama University, Fukuyama, Japan. kimura@fubac.fukuyama-u.ac.jp

Abstract

BACKGROUND:

PUFAs are susceptible to lipid peroxidation and play a role in inflammation, both of which can induce oxidative stress. However, the relation of PUFA to oxidative DNA damage in humans is elusive.

OBJECTIVE:

We examined the association between concentrations of circulatory PUFAs and urinary 8-oxo-7,8-dihydroguanine (8-oxoGua) in Japanese men and women.

DESIGN:

The subjects were 495 participants (290 men and 205 women) in a cross-sectional study in 2 municipal offices in Japan. Serum cholesterol ester (CE) and phospholipid fatty acid composition were measured by gas-liquid chromatography. Urinary 8-oxoGua concentrations were measured by HPLC, and 8-oxoGua values for each tertile of PUFA after adjustment for covariates were calculated by multiple regression.

RESULTS:

Urinary 8-oxoGua concentrations increased with increasing concentrations of n-3 (omega-3) PUFAs, EPA, and DHA in serum CE (P-trend = 0.001, 0.01, and 0.009, respectively), whereas they decreased with increasing concentrations of n-6 PUFAs and linoleic acid (P-trend = 0.02 and 0.051, respectively).

CONCLUSION:

Oxidative DNA damage may be greater with higher concentrations of long-chain n-3 PUFAs but lower with higher concentrations of n-6 (omega-6) PUFAs.

PMID:
22440849
DOI:
10.3945/ajcn.111.030817
[Indexed for MEDLINE]

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