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Curr Opin Virol. 2011 Nov;1(5):419-22. doi: 10.1016/j.coviro.2011.09.001. Epub 2011 Oct 4.

Lethal mutagenesis of viruses.

Author information

1
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, 28049, Madrid, Spain.

Abstract

Lethal mutagenesis aims at extinguishing viruses by increased mutagenesis prompted by virus-specific mutagenic agents, mainly nucleoside analogues. It is derived from the error threshold relationship of quasispecies theory, and it is slowly finding its way towards a clinical application. We summarize the current situation of research in this field of antiviral therapy.

PMID:
22440845
DOI:
10.1016/j.coviro.2011.09.001
[Indexed for MEDLINE]

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