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Sensors (Basel). 2012;12(2):2284-308. doi: 10.3390/s120202284. Epub 2012 Feb 16.

Biomarker discovery by novel sensors based on nanoproteomics approaches.

Author information

1
Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain. noeliadf@usal.es

Abstract

During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors.

KEYWORDS:

biomarker; cancer; high-throughput techniques; microarray; nanosensor; proteomics

PMID:
22438764
PMCID:
PMC3304166
DOI:
10.3390/s120202284
[Indexed for MEDLINE]
Free PMC Article
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