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J Virol. 2012 May;86(10):5948-52. doi: 10.1128/JVI.07039-11. Epub 2012 Mar 21.

Hepatitis E virus replication requires an active ubiquitin-proteasome system.

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1
Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.

Abstract

The mechanism of hepatitis E virus (HEV) replication remains largely unknown. Here we demonstrate that HEV replication requires an active ubiquitin-proteasome system and that proteasome inhibitors affect HEV replication, possibly by inhibition of viral transcription or/and translation without a significant effect on cellular translation. Overexpression of ubiquitin in inhibitor-treated cells partially reverses the inhibitor effect on HEV replication. The results suggest that HEV replication requires interactions with proteasome machinery, which could be a potential therapeutic target against HEV.

PMID:
22438536
PMCID:
PMC3347252
DOI:
10.1128/JVI.07039-11
[Indexed for MEDLINE]
Free PMC Article
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