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Br J Ophthalmol. 2012 Jun;96(6):793-5. doi: 10.1136/bjophthalmol-2011-301227. Epub 2012 Mar 21.

Diagnosis, clinical features and treatment outcome of microsporidial keratoconjunctivitis.

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Cornea and Anterior Segment Service, L. V. Prasad Eye Institute, Patia, Bhubaneswar, Odisha 751024, India.



To report the clinical and microbiological profile of patients with microsporidial keratoconjunctivitis in a tertiary eye care centre in India.


A retrospective analysis of medical records of all cases of microbiologically confirmed microsporidial keratoconjunctivitis, who presented between March 2007 and October 2010, was done. In a single-centre, institutional setting, 278 eyes of 277 apparently healthy patients were analysed.


The mean age was 36 ± 14 years (range 6-80). The mean duration of symptoms was 7.7 ± 6.2 days (range 1-60). Keratic precipitates were present in 20.1% patients. A superficial scar was present in 39.2% patients. Majority (26.6%) of the patients reported in the month of August. Microscopic examination of corneal scraping, using potassium hydroxide with calcofluor white and Gram stain, demonstrated microsporidial spores in 98.9% and 89.7% cases, respectively. Patients received either topical 0.02% polyhexamethylene biguanide or lubricants. The mean time for resolution was 6.0 ± 2.9 days (range 2-18). Final visual acuity was ≥ 20/30 in 75.1% cases.


Microsporidial keratoconjunctivitis is common in India. It is seasonal, can occur in healthy individuals and can be diagnosed using simple microbiological methods. Treatment outcome is generally satisfactory.

[Indexed for MEDLINE]

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