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Neurotherapeutics. 2012 Apr;9(2):371-9. doi: 10.1007/s13311-012-0115-z.

Nonhuman primate models of stroke for translational neuroprotection research.

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Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto Western Hospital Division of Neurosurgery, Toronto, Ontario M5T 2S8, Canada.


Despite the discovery of several promising neuroprotective therapies in rodent models of stroke, no therapy other than the fibrinolytics has been found to be effective in human clinical trials. To address potential discrepancies between rodent and human studies, the Stroke Therapy Academic Industry Roundtable (STAIR) committee suggested that nonhuman primates (NHPs) be used for preclinical, translational stroke studies. Due to the paucity of stroke studies in NHPs, few experimental models have been described. Critical factors in designing NHP stroke models include the choice of species, the method of inducing the stroke and the choice of outcome measures. In this review, we describe established NHP models of stroke and discuss factors that may influence model development with a focus on models that may be useful in preclinical studies for neuroprotective drug screening prior to clinical trials.

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