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Cell Cycle. 2012 Apr 15;11(8):1517-23. doi: 10.4161/cc.19846. Epub 2012 Apr 15.

The expanding role of miR-302-367 in pluripotency and reprogramming.

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1
Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Abstract

MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete due to experimental limitations and difficulties in identifying their physiological targets. Recent studies implicated hESC-expressed miRNAs (miR‑302-367 and miR‑371-373 clusters) in regulating BMP signaling and promoting pluripotency, suggesting that low levels of BMP signaling may promote pluripotency by preventing neural induction. A comprehensive list of miR‑302-367 targets recently identified by genome-wide approaches suggests a number of additional cellular processes and signaling pathways whose regulation by miR‑302-367 may promote pluripotency and reprogramming, such as cell cycle, epigenetic changes, metabolism and vesicular transfer.

PMID:
22436490
DOI:
10.4161/cc.19846
[Indexed for MEDLINE]
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