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Anim Health Res Rev. 2012 Jun;13(1):1-9. doi: 10.1017/S1466252312000011. Epub 2012 Mar 21.

Alphavirus replicon vaccines.

Author information

1
Harrisvaccines Inc., Ames, IA 50010, USA. rvanderveen@harrisvaccines.com

Abstract

The alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and safety features of the system and discusses the current literature on RP and replicon-based vaccines.

PMID:
22436454
DOI:
10.1017/S1466252312000011
[Indexed for MEDLINE]

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