Format

Send to

Choose Destination
Development. 2012 Apr;139(8):1371-80. doi: 10.1242/dev.072348.

Diverse roles for VEGF-A in the nervous system.

Author information

1
UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, UK.

Abstract

Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of neuronal functions, both in vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance. Recent studies have employed mouse models to distinguish the direct effects of VEGF on neurons from its indirect, vessel-mediated effects. Ultimately, refining our knowledge of VEGF signalling pathways in neurons should help us to understand how the current use of therapeutics targeting the VEGF pathway in cancer and eye disease might be expanded to promote neuronal health and nerve repair.

PMID:
22434866
DOI:
10.1242/dev.072348
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center