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Int J Epidemiol. 2013 Apr;42(2):422-9. doi: 10.1093/ije/dys028. Epub 2012 Mar 20.

Cohort profile: the Amsterdam Growth and Health Longitudinal Study.

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Department of Internal Medicine and the Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.


The Amsterdam Growth and Health Longitudinal Study (AGHLS) is a unique, multidisciplinary cohort study that was initially set up to examine growth and health among teenagers. Throughout the years, the AGHLS has aimed to answer research questions dealing with the relationships between the (natural) development of anthropometry, lifestyle and health from adolescence into adulthood. The AGHLS specifically focuses on anthropometrics, physical activity and fitness, cardiovascular disease risk, lifestyle, musculoskeletal health, psychological health and well-being. Besides this, many methodological issues related to the analysis of longitudinal data were also explored within the framework of the AGHLS. In 1976, students from two secondary schools from the greater Amsterdam area were included in the study. Between 1976 and 2006, 10 rounds of measurement were performed covering an age range between 13 and 43 years. The huge database collected so far has been primarily used to answer relevant research questions regarding the longitudinal relationship between lifestyle and health. Further information about the study can be obtained from the principal investigator Jos Twisk (, and up-to-date information on AGHLS can be found by visiting the website

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