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Adv Exp Med Biol. 2012;744:75-86. doi: 10.1007/978-1-4614-2364-5_7.

RAMP like proteins : RTP and REEP family of proteins.

Author information

1
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

Abstract

Mammalian odorant receptors (ORs) are typically retained in the endoplasmic reticulum (ER) when expressed in heterologous cells. The RTP (Receptor-Transporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.

PMID:
22434109
DOI:
10.1007/978-1-4614-2364-5_7
[Indexed for MEDLINE]

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