Format

Send to

Choose Destination
See comment in PubMed Commons below
Pathobiology. 2012;79(4):169-74. doi: 10.1159/000334837. Epub 2012 Mar 16.

Clinicopathological features of serrated adenocarcinoma defined by Mäkinen in dukes' B colorectal carcinoma.

Author information

1
Department of Surgery 1, Dokkyo University School of Medicine, Mibu, Japan.

Abstract

OBJECTIVE:

Serrated adenocarcinoma (SAC), proposed as a new pathologic type, arises predominantly in the right side of the colon and has a poorer prognosis than conventional colorectal carcinoma. The prognosis of colorectal carcinoma is variable in Dukes' B, so the aim of this study was to determine whether or not SAC has a poor prognosis in Dukes' B.

METHODS:

The study group comprised 64 patients who underwent surgery for colorectal carcinoma. We undertook a statistical analysis of the association of SAC and non-SAC with sex, age, histologic type, depth of tumor, location of tumor, venous invasion and lymphatic invasion.

RESULTS:

SACs were encountered in 17.5% of cases (n = 11). SAC had a less favorable 5-year survival than non-SAC (p = 0.0396 log-rank, Kaplan-Meier). The factors that achieved statistical significance in the univariate analysis were subsequently included in a multivariate analysis and we found that SAC was an independent factor (p = 0.027).

CONCLUSIONS:

SAC has a poor prognosis and is not affected by other factors confirming that SAC is an independently less favorable prognostic factor.

PMID:
22433973
DOI:
10.1159/000334837
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center