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Org Lett. 2012 Apr 6;14(7):1938-41. doi: 10.1021/ol3006425. Epub 2012 Mar 21.

Copper catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate.

Author information

1
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Abstract

A copper-catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate, generated from diethyl bromodifluoromethylphosphonate and zinc in dioxane, is reported. The notable features of this reaction are its high reaction efficiency, excellent functional group compatibility, and operational simplicity. This protocol provides a useful and facile access to aryldifluorophosphonates of interest in life science.

PMID:
22432425
DOI:
10.1021/ol3006425
[Indexed for MEDLINE]

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