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Nat Immunol. 2012 Mar 19;13(4):325-32. doi: 10.1038/ni.2231.

Sensing and reacting to microbes through the inflammasomes.

Author information

1
Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

Inflammasomes are multiprotein complexes that activate caspase-1, which leads to maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the induction of pyroptosis. Members of the Nod-like receptor (NLR) family, including NLRP1, NLRP3 and NLRC4, and the cytosolic receptor AIM2 are critical components of inflammasomes and link microbial and endogenous danger signals to the activation of caspase-1. In response to microbial infection, activation of the inflammasomes contributes to host protection by inducing immune responses that limit microbial invasion, but deregulated activation of inflammasomes is associated with autoinflammatory syndromes and other pathologies. Thus, understanding inflammasome pathways may provide insight into the mechanisms of host defense against microbes and the development of inflammatory disorders.

PMID:
22430785
PMCID:
PMC3449002
DOI:
10.1038/ni.2231
[Indexed for MEDLINE]
Free PMC Article

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