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Adv Cancer Res. 2012;113:45-83. doi: 10.1016/B978-0-12-394280-7.00002-6.

The microRNA regulatory network in normal- and HTLV-1-transformed T cells.

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Department of Surgical Sciences, Oncology and Gastroenterology, University of Padova, Padova, Italy.


Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.

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