Format

Send to

Choose Destination
Adv Drug Deliv Rev. 2012 Sep;64(12):1152-64. doi: 10.1016/j.addr.2012.03.003. Epub 2012 Mar 10.

Local delivery of small and large biomolecules in craniomaxillofacial bone.

Author information

1
Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Abstract

Current state of the art reconstruction of bony defects in the craniomaxillofacial (CMF) area involves transplantation of autogenous or allogenous bone grafts. However, the inherent drawbacks of this approach strongly urge clinicians and researchers to explore alternative treatment options. Currently, a wide interest exists in local delivery of biomolecules from synthetic biomaterials for CMF bone regeneration, in which small biomolecules are rapidly emerging in recent years as an interesting adjunct for upgrading the clinical treatment of CMF bone regeneration under compromised healing conditions. This review highlights recent advances in the local delivery small and large biomolecules for the clinical treatment of CMF bone defects. Further, it provides a perspective on the efficacy of biomolecule delivery in CMF bone regeneration by reviewing presently available reports of pre-clinical studies using various animal models.

PMID:
22429663
DOI:
10.1016/j.addr.2012.03.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center