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Atherosclerosis. 2012 May;222(1):270-3. doi: 10.1016/j.atherosclerosis.2012.02.026. Epub 2012 Feb 23.

Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies.

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Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.



Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies.


We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model.


A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03).


Our results do not support a protective role of flavonols intake against CHD.

[Indexed for MEDLINE]

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