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Crit Rev Immunol. 2012;32(1):23-63.

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.

Author information

1
Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

Abstract

Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.

PMID:
22428854
PMCID:
PMC3410706
[Indexed for MEDLINE]
Free PMC Article

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