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Nat Chem Biol. 2012 Mar 18;8(5):431-3. doi: 10.1038/nchembio.915.

Signaling-mediated bacterial persister formation.

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1
Howard Hughes Medical Institute, Boston University, Boston, Massachusetts, USA.

Abstract

Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics and identify the role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling 'inoculates' a bacterial subpopulation against antibiotics by activating stress responses, leading to persister formation.

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PMID:
22426114
PMCID:
PMC3329571
DOI:
10.1038/nchembio.915
[Indexed for MEDLINE]
Free PMC Article
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