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J Colloid Interface Sci. 2012 Jun 1;375(1):88-93. doi: 10.1016/j.jcis.2012.02.042. Epub 2012 Mar 3.

A micellization study of medium chain length poly(3-hydroxyalkanoate)-based amphiphilic diblock copolymers.

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1
Institut de Chimie et des Matériaux Paris-Est (ICMPE), Systèmes Polymères, Complexes, UMR CNRS 7182, Thiais, France.

Abstract

In this article, we report the first micellization study of amphiphilic copolymers composed of bacterial medium chain length poly(3-hydroxyalkanoates) (mcl-PHAs). A series of diblock copolymers based on fixed poly(ethylene glycol) (PEG) block (5000 g mol(-1)) and a varying poly(3-hydroxyoctanoate-co-3-hydroxyhexanoate) (PHOHHx) segment (1500-7700 g mol(-1)) have been synthesized using "click" chemistry. These copolymers self-assembled to form micelles in aqueous media. The influence of PHOHHx block molar mass on the hydrodynamic size and on the critical micelle concentration (CMC) has been studied using dynamic light scattering and fluorescence spectroscopy, respectively. With increasing PHOHHx length, narrowly distributed micelles with diameters ranging from 44 to 90 nm were obtained, with extremely low CMC (up to 0.85 mg/L). Cryogenic transmission electron microscopy (Cryo-TEM) showed that micelles took on a spherical shape and exhibited narrow polydispersity. Finally, the colloidal stability of the micelles against physiological NaCl concentration has been demonstrated, suggesting they are promising candidates for drug delivery applications.

PMID:
22424814
DOI:
10.1016/j.jcis.2012.02.042
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