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Curr Opin Genet Dev. 2012 Apr;22(2):62-71. doi: 10.1016/j.gde.2012.02.007. Epub 2012 Mar 16.

New and Xisting regulatory mechanisms of X chromosome inactivation.

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1
Howard Hughes Medical Institute, Dept. of Molecular Biology, Massachusetts General Hospital, Dept. of Genetics, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Equalization of X linked gene expression is necessary in mammalian cells due to the presence of two X chromosomes in females and one in males. To achieve this, all female cells inactivate one of the two X chromosomes during development. This process, termed X chromosome inactivation (XCI), is a quintessential epigenetic phenomenon and involves a complex interplay between noncoding RNAs and protein factors. Progress in this area of study has consequently resulted in new approaches to study epigenetics and regulatory RNA function. Here we will discuss recent developments in the field that have advanced our understanding of XCI and its regulatory mechanisms.

PMID:
22424802
PMCID:
PMC3361064
DOI:
10.1016/j.gde.2012.02.007
[Indexed for MEDLINE]
Free PMC Article
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