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Cell. 2012 Mar 16;148(6):1172-87. doi: 10.1016/j.cell.2012.02.005.

MicroRNAs in stress signaling and human disease.

Author information

1
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9148, USA. joshua.mendell@utsouthwestern.edu

Abstract

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

PMID:
22424228
PMCID:
PMC3308137
DOI:
10.1016/j.cell.2012.02.005
[Indexed for MEDLINE]
Free PMC Article

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