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Cell. 2012 Mar 16;148(6):1081-4. doi: 10.1016/j.cell.2012.02.034.

Antibody-based immunotherapy of cancer.

Author information

1
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington, DC 20007, USA. weinerl@georgetown.edu

Abstract

By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss these innovative strategies and propose how they will impact the future of antibody-based cancer therapy.

PMID:
22424219
PMCID:
PMC3310896
DOI:
10.1016/j.cell.2012.02.034
[Indexed for MEDLINE]
Free PMC Article

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