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Breast Cancer Res. 2012 Mar 16;14(2):304.

BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control.

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1
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet, Barcelona, Catalonia, Spain.

Abstract

BRCA1 is a tumor suppressor gene known to be implicated in the development of a subset of breast and ovarian cancers. The tumor suppressor properties of BRCA1 are generally thought to be linked to the gene's critical roles in the network of DNA damage response. In a recent report, BRCA1-mediated epigenetic repression at the promoter region of miRNA-155 was identified as a novel mechanism by which BRCA1 carries out its tumor suppressor functions.

PMID:
22423979
PMCID:
PMC3446364
DOI:
10.1186/bcr3119
[Indexed for MEDLINE]
Free PMC Article
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