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Sci Transl Med. 2012 Mar 14;4(125):125sr1. doi: 10.1126/scitranslmed.3003504.

Treating human autoimmunity: current practice and future prospects.

Author information

1
Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA. rosenblummd@derm.ucsf.edu

Abstract

Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression.

PMID:
22422994
PMCID:
PMC4061980
DOI:
10.1126/scitranslmed.3003504
[Indexed for MEDLINE]
Free PMC Article
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