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Vaccine. 2012 May 2;30(21):3147-50. doi: 10.1016/j.vaccine.2012.02.078. Epub 2012 Mar 13.

Hepatitis B vaccination of susceptible elderly residents of long term care facilities during a hepatitis B outbreak.

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1
Division of Viral Hepatitis, Centers for Disease Control, Prevention, Atlanta, GA, United States.

Abstract

Protection of older persons, particularly those with diabetes, against hepatitis B virus (HBV) infection is of growing concern because of increased reports of outbreaks among long-term care facility residents receiving assisted blood glucose monitoring. We evaluated hepatitis B vaccine immunogenicity among residents immunized in response to two such outbreaks in skilled nursing facilities during June 2009-July 2010. One hundred forty-eight (71%) of 209 residents were found to be susceptible to HBV infection. Of 105 patients who began a vaccination series with Twinrix(®) (0-, 1-, 6-month dosing), 86 (82%) completed the series and postvaccination testing. Of these, most were elderly (median age 79.5 years; range 45-101), female (56%), and African-American (51%). Twenty-nine (34%) vaccinated residents had post-vaccination hepatitis B surface antibody levels ≥10 mIU/ml. There were no significant differences in vaccine response by age, gender, race, diabetes status, body mass index, or current smoking status. Our findings indicate that a low proportion of skilled nursing facility residents achieved a seroprotective response after hepatitis B vaccination.

PMID:
22421557
DOI:
10.1016/j.vaccine.2012.02.078
[Indexed for MEDLINE]

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