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Dev Cell. 2012 Mar 13;22(3):472-4. doi: 10.1016/j.devcel.2012.02.014.

A local view of cancer.

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Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.


Research on solid tumors has had limited emphasis on interactions between transformed cells and their neighbors within the epithelium. Leung and Brugge (2012) use cultured breast cancer acini to demonstrate the importance of local interactions between normal and transformed epithelial cells, with important implications for our understanding of epithelial cancers.

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