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Arthritis Rheum. 1990 Nov;33(11):1665-73.

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

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1
Department of Internal Medicine, University of Michigan, Ann Arbor.

Abstract

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.

PMID:
2242063
[Indexed for MEDLINE]
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