Format

Send to

Choose Destination
See comment in PubMed Commons below
J Virol. 2012 May;86(10):5922-5. doi: 10.1128/JVI.07060-11. Epub 2012 Mar 14.

Abortive replication of influenza virus in mouse dendritic cells.

Author information

1
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.

Abstract

The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein, at least, being produced. Electron microscopy reveals that virus assembly, rather than release of virus from the cell surface, is defective.

PMID:
22419813
PMCID:
PMC3347256
DOI:
10.1128/JVI.07060-11
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center