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Bioinformatics. 2012 May 1;28(9):1294-6. doi: 10.1093/bioinformatics/bts127. Epub 2012 Mar 13.

IsoCor: correcting MS data in isotope labeling experiments.

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Université de Toulouse, 135 Avenue de Rangueil, Toulouse, France.


Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications-e.g. metabolic flux analysis-require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known ((13)C, (15)N, (18)O, etc) to unusual ((57)Fe, (77)Se, etc) isotopes. It also provides new features-e.g. correction for the isotopic purity of the tracer-to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community.


IsoCor is distributed under OpenSource license at

[Indexed for MEDLINE]

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