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Stem Cells. 2012 May;30(5):797-803. doi: 10.1002/stem.1066.

Concise review: Immune recognition of induced pluripotent stem cells.

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1
NIH Center of Biomedical Research Excellence in Stem Cell Biology, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island 02908, USA. asboyd@bu.edu

Abstract

Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies.

PMID:
22419544
DOI:
10.1002/stem.1066
[Indexed for MEDLINE]
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