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Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.

The immune contexture in human tumours: impact on clinical outcome.

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1
INSERM UMRS872, Laboratory of Immune microenvironment and tumours, Paris F75006, France.

Abstract

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

PMID:
22419253
DOI:
10.1038/nrc3245
[Indexed for MEDLINE]
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