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Epigenetics. 2012 Apr;7(4):340-3. doi: 10.4161/epi.19506. Epub 2012 Apr 1.

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

Author information

1
GlaxoSmithKline, Collegeville, PA, USA.

Abstract

Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease.

PMID:
22419068
PMCID:
PMC3368817
DOI:
10.4161/epi.19506
[Indexed for MEDLINE]
Free PMC Article

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