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J Invest Dermatol. 2012 Apr;132(4):1068-70. doi: 10.1038/jid.2012.25.

Mediator1: an important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology.

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Charlie Norwood VA Medical Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA.


Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathway's importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.

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