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Immunol Res. 2012 Sep;53(1-3):11-24. doi: 10.1007/s12026-012-8291-9.

Macrophage polarization and plasticity in health and disease.

Author information

1
Singapore Immunology Network, Agency for Science, Technology & Research (A*STAR) Biopolis, #04 Immunos, 8A Biomedical Grove, Singapore. subhra_biswas@immunol.a-star.edu.sg

Abstract

The role of myelomonocytic cells like monocytes and macrophages as first line of host defense is well established. Recent understanding of these cells using systems biology, transgenesis and in disease models has brought them to a center stage in orchestrating crucial functions during homeostasis and pathogenesis. Thus, understanding the functional diversity of these cells in health and disease as well as the mechanisms that control these events would be crucial for designing strategies for regulating disease and reinstate homeostasis.

PMID:
22418728
DOI:
10.1007/s12026-012-8291-9
[Indexed for MEDLINE]

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