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Curr Opin HIV AIDS. 2012 May;7(3):276-82. doi: 10.1097/COH.0b013e32835211e9.

Mechanisms of interaction between protozoan parasites and HIV.

Author information

1
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec - CHUL, Québec, Québec, Canada.

Abstract

PURPOSE OF REVIEW:

This review summarizes the current knowledge on human immunodeficiency virus type 1 (hereinafter called HIV)/protozoan co-infections in the case of three important, although neglected, tropical diseases: malaria, trypanosomiasis (Chagas disease) and leishmaniasis. The HIV pandemic has modified the immunopathogenic, epidemiological and therapeutic aspects of these human diseases.

RECENT FINDINGS:

In-vitro data suggests that HIV favors Leishmania infection, whereas different parasites have contrasting effects on HIV. However, many of the previous models are a limited representation of the complex interactions within the host; this situation is particularly the case when microbial products are used in place of live parasites.

SUMMARY:

In the host, protozoan parasites generally enhance HIV replication and accelerate AIDS progression. HIV alters parasite pathogenesis, often worsening disease outcome. These aspects bring significant complications for the treatment of co-infected individuals.

PMID:
22418447
DOI:
10.1097/COH.0b013e32835211e9
[Indexed for MEDLINE]

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